Yes.
The PalmOS is well supported by Linux, you can use kpilot or gnome-pilot to sync. More interestingly, and this is for the Tungsten E palm, ie not the product on woot, is the project to
run Linux on the palm itself. The extent of whats required is to dd a (specific) image to an SD card and reboot your Palm.
As a side note, Palm has been rumored to be moving to a Linux based platform to replace its aging Palm platform for ages now.
:)